Prague, 6 May 1996

Mr.

Dr S.C. MacDiarmid

National Manager

Agriculture Security and Animal Health

Ministry of Agriculture and Fisheries

P.O. Box 2526

Wellington

N E W   Z E A L A N D

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Dear Dr MacDiarmid,

 

    thank you very much for your interesting letter of 15 January 1996 reacting to my letter of 13 December 1995 regarding our opinions on animal disease risk analysis.

 

    First, few words on your statement "If, for a particular trade, we have available reducing tools (tests, treatment, whatever ) which will reduce the risk by 10,000 or 100,000 times, what does it matter what the starting risk was ?"  Risk reduction measures can be sufficiently effective in case of products to be processed destroying eventual pathogens - disinfected or sterilized. However, this is not the case when importing animals and crude products where we depend a lot on reported situation and test results. These results are almost never reliable for 100 % depending on specificity and sensitivity of the methods used, range and frequency of investigations, interpretation of the results as well as on investigators professional level. Sometimes human errors cannot be avoided. Negative diagnostic test results not always correspond with the reality (referring also to your methods based on starting risk described in Rev. sci. tech. int. Epiz., 1993, 12, p. 1093-1107).

 

  The problem is usually multi-etiological risk and not only mono-etiological one. I agree that the priority have the diseases of the OIE list A. But internationally reported are about 150 diseases. Several hundreds of not controlled but important diseases (including many zoonoses) spread also through export/import of animals and their crude products without any protective measures (specific import conditions) and risk reduction procedure.

 

    Importing country needs to import healthy animals and innocuous products and not to be depended on risk reducing measures only without considering starting risk. Majority of reducing procedures are usually not for 100 % reliable and cost money, time and material. It is preferable to import under zero-risk or under minimal possible starting risk.  The concept of OIE International Animal Health Code is based correctly on defining conditions for zero or minimal starting risk in List A and B disease.

 

   We cannot under-estimate veterinary services evaluation. For example see Guidelines for the evaluation of Veterinary Services "as an important element in risk assessment process" (Ref.: Rev.sci.tech.Off.int.Epiz., 1993, 12(4), 1291-1313).

 

      There are many examples that in spite of mathematical risk assessment, all the risk reducing measures and perfect veterinary certification many specific diseases  were spread through animal commodities to other countries including specific diseases free ones or where these diseases have (not easily) been eradicated.  The losses caused by introduced disease can be enormous and usually not covered (paid) by exporting country.

 

a) Bovine spongiform encephalopathy spread by import from U.K. to Republic of Ireland, Falkland Islands, Portugal, France, Denmark, Switzerland, Oman etc. BSE belongs among so called "new emerging diseases" not yet well known and controlled.  BSE in U.K. is provoking catastrophic consequences of biological, economic, social and political characters. According to "Business Week" the  economic loss is estimated about 15 billions of dollars ! U.K. had to kill already about 160 000 BSE diseased and suspect cattle during the last decade. And now it should be probably about half a million of cows to kill following the request of international organizations as the condition for ending cattle and beef export blockade. This alarm was caused due to the suspicion of transmissibility of this killing disease to human beings which has not yet been confirmed ! What about the consequences if this hypothesis of zoonosis would be proved ?!

b) Hog cholera introduced by import of pigs and pork products: Belgium in 1990/1991 one million pigs lost, Germany in 1993/1994 1.5 million pigs lost - loss US$ 1 billion ! FMD in U.K. introduced by beef from Southern America in 1967 - loss 430 000 diseased and suspected animals. (Ref.:  J. Blancou and F.-X. Meslin: International trade and human or animal diseases: a historical review. World Veterinary Congress, Yokohama, 1995).

c) Eradication of screwworm (Cochliomyia hominivorax) introduced to Northern Africa by sheep for slaughter from Southern America in 1988 cost more than US$ 80 millions, beside direct and indirect losses and consequences.

 

You can see that in spite of all risk reducing measures we could not avoid the introduction of these pathogens by so called "save" import.


 

 There are many example of spreading of "imported diseases" from primary outbreaks creating many secondary ones requiring costly and demanding eradication measures. Examples: Ratios primary/secondary foot-and-mouth outbreaks in EEC country in years 1977-1987: Portugal - 591 (!!), Italy - 42, France - 19, Denmark - 10, etc. (Ref.: G.Davies, Rev. sci. tech. int. Epiz., 1993, 12, p.1115). This demonstrates once more, that also in developed countries with veterinary services of good references is not easy to catch the first outbreak and block the spreading. What about the developing countries with  weak government veterinary service short of manpower, funds, material, vaccines, transport and communication means, laboratory diagnostic facilities, etc.? And FMD is a disease with short incubation and clear cut clinical manifestation ! What about slowly spreading diseases with insidious course, long incubation (e.g. BSE up to 5 years, brucellosis and tuberculosis up to several years, etc.), requiring laboratory testing for confirmation (clinical cases representing only a very limited proportion of real prevalence), etc. ? How this diseases' situation can be evaluated without wide range and frequent active etiological investigations ? This question is applicable also for importing country, how it can be sure that no any disease has been introduced by import. If no active search is carried out than we can use only on very rough estimates.

 

  I remember that in 1981, when I was Chief-editor of the FAO-OIE-WHO Animal Health Yearbook, Lesotho government instead of returning the questionnaire reported by cable that no animal diseases exist in the country. That time Lesotho had only two national veterinarians, one as refugee in Botswana and one in an office in Europe. No government service = no investigations = no discovered diseases = no problem with export = no trouble with traders and no problem for government budget (everybody happy??) ?!?.

 

   This is once more a reason for giving priority to zero or minimum starting risk in exporting countries and so try to prevent disease introduction and avoid serious negative consequences requiring also expenses to be covered by government budget (paid by the country tax payers).

 

    As I mentioned in my previous letter, there is a substantial difference of the risk between the import of animate and inanimate commodities. Circulation of etiological agents and transmissibility of infectious animal diseases is often very complex, not always well known, difficult to control and is very different according to individual animal species and their specific products as well as according to particular external conditions. The most dangerous are the animals - asymptomatic carriers of specific pathogens.

 

 I am a bit afraid that veterinary conditions for international trade in animals and their products can be sometimes abused in "trade war". I feel the consequences of so called "new trade international policy" also in the fact that for the first time a lot of countries did not return the usual annual questionnaire for international animal health/disease information system: In FAO-OIE-WHO Animal Health Yearbook 1994 73 countries (not only developing ones) are missing , i.e. one third of world ! Lack of international epizootiological information can easily contribute to open the door to inter-country spreading of animal diseases.

 

    I would like to stress once again that every case is different depending on many aspects. It cannot be used one fixed model for all the types of export/import commodities and for all circumstances, conditions and needs. According to my opinion, when assessing disease introduction risk, beside biological scientific aspects, also type, purpose, distribution and use of the commodity, credibility of exporting country as well as previous  experience   with it should be considered. Priority must be given to maximum possible protection of specific diseases free populations and territories. 

    

    We must be very and very cautious when assessing the disease risk for import decisions ! We have to try as much as possible to find solutions acceptable not only for traders but first of all for specific diseases free country (territory) protection. This is also our responsibility toward importing country farmers, consumers and economy.

 

    The main criterion of all theory, including risk assessment methods and interpretation, is the practical impact and final result ! The number of new cases of spreading diseases through the export of animals and their products is increasing due to disease risk under-estimation . On the other hand, the number of cases when the countries report success story of eradication of these diseases is very sporadic and decreasing ! The result is that the animal population health situation in the world is getting worse and thus in the future their control and eradication will be much more difficult and very costly, if feasible at all. Not speaking about negative economic impact and public health consequences of spreading zoonoses. This fact is not of interest for international businessmen who call for maximum benevolence in defining veterinary import conditions. However, veterinary services and international organizations must concern about this risky situation.

 

    Mathematical analysis itself cannot replace a complex analysis done by veterinary professionals considering all relevant factors. Nevertheless, I hope that the mathematical risk assessment will have better fate than disease eradication mathematical modeling without field follow-up actions, i.e. without reaching real eradication.

 

    Once again, I would like to thanks for the interesting exchange of opinion and observations between us on this particular subject. I hope too that we get the chance to meet us again soon.

 

                                Yours sincerely,

 

 

 

                             Prof.Dr Vaclav  K o u b a, DrSc.

                                P.B. 516, 17000 Prague 7

                                Czech Republic

 

 

 

 

         

    I would like to stress once again the right of importing country veterinary services authorities responsible for country protection to decide the conditions asking for zero or for acceptable risk guaranties and this should be respected by exporting country without any dictate or imposing other conditions from abroad.